| 1 | Alexa BrugerePlace 1 · Grade 12 · Francis Howell | 12 | Francis Howell | 2:23.65 |
| 2 | Shonjahnae GriggsPlace 2 · Grade 11 · East St. Louis | 11 | East St. Louis | 2:25.37 |
| 3 | Maggie MayPlace 3 · Grade 9 · Francis Howell | 9 | Francis Howell | 2:28.75 |
| 4 | Nadia PulliamPlace 4 · Grade 12 · Hazelwood West | 12 | Hazelwood West | 2:30.79 |
| 5 | Maysha VickersPlace 5 · Grade Jr · East St. Louis | Jr | East St. Louis | 2:31.92 |
| 6 | Lila BenskyPlace 6 · Grade 11 · Ladue Horton Watkins | 11 | Ladue Horton Watkins | 2:32.83 |
| 7 | Bella RacettePlace 7 · Grade 12 · Nerinx Hall | 12 | Nerinx Hall | 2:33.02 |
| 8 | Marie PrindivillePlace 8 · Grade 9 · Nerinx Hall | 9 | Nerinx Hall | 2:33.81 |
| 9 | Katherine DudleyPlace 9 · Grade 12 · Rock Bridge | 12 | Rock Bridge | 2:33.83 |
| 10 | Audrey KellyPlace 10 · Grade 11 · Ft. Zumwalt East | 11 | Ft. Zumwalt East | 2:38.53 |
| 11 | Makenna SeghersPlace 11 · Grade 9 · Holt | 9 | Holt | 2:38.56 |
| 12 | Anna JohnstonPlace 12 · Grade 10 · St. Charles | 10 | St. Charles | 2:39.84 |
| 13 | Grace ChicoinePlace 13 · Grade 11 · Ladue Horton Watkins | 11 | Ladue Horton Watkins | 2:39.86 |
| 14 | Molly RolwesPlace 14 · Grade 10 · Cor Jesu Academy | 10 | Cor Jesu Academy | 2:40.41 |
| 15 | Sally GacheruPlace 15 · Grade 11 · Hazelwood West | 11 | Hazelwood West | 2:40.46 |
| 16 | Lindsey JohnstonPlace 16 · Grade 12 · Troy-Buchanan | 12 | Troy-Buchanan | 2:41.04 |
| 17 | Nicole GriesenauerPlace 17 · Grade 12 · Holt | 12 | Holt | 2:41.37 |
| 18 | Desiree BrooksPlace 18 · Grade 12 · Hazelwood West | 12 | Hazelwood West | 2:42.83 |
| 19 | Jadie ArnettPlace 19 · Grade 12 · Rock Bridge | 12 | Rock Bridge | 2:44.14 |
| 20 | Marisa LongPlace 20 · Grade 10 · Hazelwood Central | 10 | Hazelwood Central | 2:44.47 |
| 21 | Kaelyn KovarikPlace 21 · Grade 12 · Rock Bridge | 12 | Rock Bridge | 2:44.53 |
| 22 | Catherine JacknewitzPlace 22 · Grade 11 · Nerinx Hall | 11 | Nerinx Hall | 2:45.78 |
| 23 | Kendall BrownPlace 23 · Grade 9 · Trinity Catholic | 9 | Trinity Catholic | 2:46.02 |
| 24 | Mercedes UptonPlace 24 · Grade 10 · St. Charles | 10 | St. Charles | 2:47.63 |
| 25 | Grace GarnerPlace 25 · Grade 11 · Notre Dame (Saint Louis) | 11 | Notre Dame (Saint Louis) | 2:48.60 |
| 26 | Karlon'Tajhi MobleyPlace 26 · Grade 10 · East St. Louis | 10 | East St. Louis | 2:49.06 |
| 27 | Avery McGeePlace 27 · Grade 9 · Ft. Zumwalt North | 9 | Ft. Zumwalt North | 2:49.08 |
| 28 | Alaina SernaPlace 28 · Grade 9 · Ft. Zumwalt North | 9 | Ft. Zumwalt North | 2:49.76 |
| 29 | Anna MeyerPlace 29 · Grade 10 · Ft. Zumwalt North | 10 | Ft. Zumwalt North | 2:50.97 |
| 30 | Ashley TurpinPlace 30 · Grade 10 · Ft. Zumwalt East | 10 | Ft. Zumwalt East | 2:51.89 |
| 31 | Mary MittsPlace 31 · Grade 9 · Troy-Buchanan | 9 | Troy-Buchanan | 2:52.50 |
| 32 | Tiffany CampbellPlace 32 · Grade 12 · McCluer South-Berkeley | 12 | McCluer South-Berkeley | 2:53.72 |
| 33 | Isobel DernlanPlace 33 · Grade 10 · Cor Jesu Academy | 10 | Cor Jesu Academy | 2:53.86 |
| 34 | Ayanna SpearsPlace 34 · Grade 9 · Ft. Zumwalt East | 9 | Ft. Zumwalt East | 2:54.25 |
| 35 | J'nyah ElbertPlace 35 · Grade 9 · Parkway Central | 9 | Parkway Central | 2:54.59 |
| 36 | Karissa BradburyPlace 36 · Grade 9 · McCluer North | 9 | McCluer North | 2:55.23 |
| 37 | Anna FiaccoPlace 37 · Grade 11 · Ladue Horton Watkins | 11 | Ladue Horton Watkins | 2:57.30 |
| 38 | Meghan MaddenPlace 38 · Grade 12 · Notre Dame (Saint Louis) | 12 | Notre Dame (Saint Louis) | 3:01.54 |
| 39 | Deaja JacksonPlace 39 · Grade 9 · McCluer North | 9 | McCluer North | 3:02.43 |
| 40 | Nakeisha MartinPlace 40 · Grade 9 · Cahokia | 9 | Cahokia | 3:08.68 |
| 41 | LaSean SaylesPlace 41 · Grade 9 · Cahokia | 9 | Cahokia | 3:10.44 |
| 42 | Taya RayPlace 42 · Grade 11 · Cahokia | 11 | Cahokia | 3:13.67 |
| 43 | Jania LeePlace 43 · Grade 12 · Hazelwood Central | 12 | Hazelwood Central | 3:14.38 |
| 44 | Mikaela LoucksPlace 44 · Grade 12 · Cor Jesu Academy | 12 | Cor Jesu Academy | 3:17.60 |
| 45 | Marquia LongPlace 45 · Grade 12 · Hazelwood Central | 12 | Hazelwood Central | 3:33.00 |