| 1 | Grace TysonPlace 1 · Grade 9 · Lafayette (W.) | 9 | Lafayette (W.) | 19:09.56 | 1 |
| 2 | Ally KrugerPlace 2 · Grade 10 · Liberty (W.) | 10 | Liberty (W.) | 19:17.67 | 2 |
| 3 | Leah KleekampPlace 3 · Grade 10 · Eureka | 10 | Eureka | 19:17.83 | 3 |
| 4 | Anna LombardoPlace 4 · Grade 11 · Eureka | 11 | Eureka | 19:29.59 | 4 |
| 5 | Madilyn MoorePlace 5 · Grade 11 · Timberland | 11 | Timberland | 19:35.32 | 5 |
| 6 | Mia ReedPlace 6 · Grade 11 · Washington | 11 | Washington | 19:38.34 | 6 |
| 7 | Julia DonnellyPlace 7 · Grade 9 · Washington | 9 | Washington | 19:43.40 | 7 |
| 8 | Emma PuetzPlace 8 · Grade 12 · Rolla | 12 | Rolla | 19:46.10 | — |
| 9 | Kathryn YatesPlace 9 · Grade 10 · Parkway West | 10 | Parkway West | 19:47.00 | 8 |
| 10 | Jessica DonnellyPlace 10 · Grade 11 · Washington | 11 | Washington | 19:50.92 | 9 |
| 11 | Mack FlynnPlace 11 · Grade 10 · Francis Howell | 10 | Francis Howell | 20:00.82 | 10 |
| 12 | Abbigael WoodsPlace 12 · Grade 12 · Liberty (W.) | 12 | Liberty (W.) | 20:01.85 | 11 |
| 13 | Hope WarePlace 13 · Grade 11 · Lafayette (W.) | 11 | Lafayette (W.) | 20:02.95 | 12 |
| 14 | Madelyn GrayPlace 14 · Grade 11 · Ft. Zumwalt South | 11 | Ft. Zumwalt South | 20:04.59 | — |
| 15 | Sarah RussomPlace 15 · Grade 11 · Francis Howell | 11 | Francis Howell | 20:06.86 | 13 |
| 16 | Katelynn QuadePlace 16 · Grade 11 · Marquette | 11 | Marquette | 20:09.59 | 14 |
| 17 | Claire MeischPlace 17 · Grade 12 · Northwest | 12 | Northwest | 20:14.03 | — |
| 18 | Tabitha BevanPlace 18 · Grade 10 · Parkway North | 10 | Parkway North | 20:16.18 | — |
| 19 | Kayla VoelkerPlace 19 · Grade 11 · Eureka | 11 | Eureka | 20:16.88 | 15 |
| 20 | Gracyn PietrusinskiPlace 20 · Grade 12 · Holt | 12 | Holt | 20:17.08 | — |
| 21 | Victoria PenneyPlace 21 · Grade 12 · Marquette | 12 | Marquette | 20:20.88 | 16 |
| 22 | Lauren HirschPlace 22 · Grade 11 · Ft. Zumwalt South | 11 | Ft. Zumwalt South | 20:25.40 | — |
| 23 | Lydia LehmbeckPlace 23 · Grade 11 · Ft. Zumwalt West | 11 | Ft. Zumwalt West | 20:29.39 | — |
| 24 | Magdalena SingletonPlace 24 · Grade 9 · Parkway South | 9 | Parkway South | 20:29.74 | — |
| 25 | Alexis EdgarPlace 25 · Grade 12 · Francis Howell | 12 | Francis Howell | 20:30.23 | 17 |
| 26 | Ryley PoseyPlace 26 · Grade 9 · Northwest | 9 | Northwest | 20:31.78 | — |
| 27 | Samantha BrownPlace 27 · Grade 10 · Northwest | 10 | Northwest | 20:33.48 | — |
| 28 | Izzy FrostPlace 28 · Grade 9 · Rolla | 9 | Rolla | 20:34.00 | — |
| 29 | Emily SippPlace 29 · Grade 11 · Parkway West | 11 | Parkway West | 20:34.06 | 18 |
| 30 | Erika WrobPlace 30 · Grade 10 · Eureka | 10 | Eureka | 20:35.32 | 19 |
| 31 | Livia VotrubaPlace 31 · Grade 9 · Timberland | 9 | Timberland | 20:37.50 | 20 |
| 32 | Maddie BennettPlace 32 · Grade 12 · F.H.C. | 12 | F.H.C. | 20:38.42 | — |
| 33 | Savannah LesherPlace 33 · Grade 11 · Eureka | 11 | Eureka | 20:42.19 | 21 |
| 34 | Riley GoringPlace 34 · Grade 11 · Marquette | 11 | Marquette | 20:45.43 | 22 |
| 35 | Elissa BarnardPlace 35 · Grade 9 · Lafayette (W.) | 9 | Lafayette (W.) | 20:48.11 | 23 |
| 36 | Claire PelchmanPlace 36 · Grade 10 · Rockwood Summit | 10 | Rockwood Summit | 20:55.03 | — |
| 37 | Hannah RossmanPlace 37 · Grade 11 · Liberty (W.) | 11 | Liberty (W.) | 20:55.16 | 24 |
| 38 | Kennedy WhitakerPlace 38 · Grade 9 · Parkway West | 9 | Parkway West | 20:55.19 | 25 |
| 39 | Kylie GhormleyPlace 39 · Grade 11 · Eureka | 11 | Eureka | 20:58.88 | 26 |
| 40 | Morgan PuszkarPlace 40 · Grade 9 · Timberland | 9 | Timberland | 21:00.79 | 27 |
| 41 | Megan VenturellaPlace 41 · Grade 10 · Liberty (W.) | 10 | Liberty (W.) | 21:03.11 | 28 |
| 42 | Mckenna JacquinPlace 42 · Grade 11 · Washington | 11 | Washington | 21:03.43 | 29 |
| 43 | Jackie HensleyPlace 43 · Grade 12 · Jefferson City | 12 | Jefferson City | 21:05.60 | — |
| 44 | Anna WarrenPlace 44 · Grade 12 · Marquette | 12 | Marquette | 21:05.74 | 30 |
| 45 | Virginia HardyPlace 45 · Grade 11 · Parkway West | 11 | Parkway West | 21:09.48 | 31 |
| 46 | Alexandra EtchasonPlace 46 · Grade 9 · Parkway West | 9 | Parkway West | 21:14.88 | 32 |
| 47 | Molly NemnichPlace 47 · Grade 10 · Lafayette (W.) | 10 | Lafayette (W.) | 21:17.32 | 33 |
| 48 | Katie ReedPlace 48 · Grade 11 · Lafayette (W.) | 11 | Lafayette (W.) | 21:18.29 | 34 |
| 49 | Brooke HiltonPlace 49 · Grade 12 · Parkway Central | 12 | Parkway Central | 21:19.86 | — |
| 50 | Kate CooperPlace 50 · Grade 9 · Timberland | 9 | Timberland | 21:20.04 | 35 |
| 51 | Erin SchweitzerPlace 51 · Grade 9 · Marquette | 9 | Marquette | 21:20.83 | 36 |
| 52 | Haley WrobPlace 52 · Grade 10 · Eureka | 10 | Eureka | 21:23.60 | 37 |
| 53 | Madelyn NewsomPlace 53 · Grade 12 · Waynesville | 12 | Waynesville | 21:29.26 | — |
| 54 | Jenna RamadanPlace 54 · Grade 10 · Timberland | 10 | Timberland | 21:30.43 | 38 |
| 55 | Anjali ShahPlace 55 · Grade 12 · Parkway West | 12 | Parkway West | 21:32.09 | 39 |
| 56 | Anna ButlerPlace 56 · Grade 11 · Parkway West | 11 | Parkway West | 21:32.77 | 40 |
| 57 | Alexa LambPlace 57 · Grade 10 · Helias Catholic | 10 | Helias Catholic | 21:32.82 | — |
| 58 | Kelsey JohnsonPlace 58 · Grade 11 · Lafayette (W.) | 11 | Lafayette (W.) | 21:33.47 | 41 |
| 59 | Lillian NixPlace 59 · Grade 11 · Washington | 11 | Washington | 21:34.97 | 42 |
| 60 | Molly MorrisPlace 60 · Grade 11 · Liberty (W.) | 11 | Liberty (W.) | 21:37.85 | 43 |
| 61 | Claudia NicholsPlace 61 · Grade 12 · Hannibal | 12 | Hannibal | 21:39.09 | — |
| 62 | Sophie YereshchenkoPlace 62 · Grade 10 · Lafayette (W.) | 10 | Lafayette (W.) | 21:51.62 | 44 |
| 63 | Belle HillPlace 63 · Grade 11 · Ft. Zumwalt North | 11 | Ft. Zumwalt North | 21:54.04 | — |
| 64 | Danielle BukerPlace 64 · Grade 9 · Helias Catholic | 9 | Helias Catholic | 22:04.97 | — |
| 65 | Ella ThierPlace 65 · Grade 9 · Rockwood Summit | 9 | Rockwood Summit | 22:08.14 | — |
| 66 | Adrienne RockettePlace 66 · Grade 10 · Liberty (W.) | 10 | Liberty (W.) | 22:09.30 | 45 |
| 67 | Hailey GerardPlace 67 · Grade 10 · Ft. Zumwalt South | 10 | Ft. Zumwalt South | 22:15.91 | — |
| 68 | Alessandra MadridPlace 68 · Grade 10 · Ft. Zumwalt West | 10 | Ft. Zumwalt West | 22:20.07 | — |
| 69 | Allison MeyerPlace 69 · Grade 11 · Washington | 11 | Washington | 22:20.15 | 46 |
| 70 | Ally FitzgeraldPlace 70 · Grade 10 · Marquette | 10 | Marquette | 22:25.69 | 47 |
| 71 | Ally HoppePlace 71 · Grade 11 · Francis Howell | 11 | Francis Howell | 22:26.26 | 48 |
| 72 | Nina ZimmermannPlace 72 · Grade 9 · Washington | 9 | Washington | 22:26.85 | 49 |
| 73 | Carolyn ShortPlace 73 · Grade 10 · Ft. Zumwalt West | 10 | Ft. Zumwalt West | 22:28.73 | — |
| 74 | Madison BodePlace 74 · Grade 9 · Marquette | 9 | Marquette | 22:35.41 | 50 |
| 75 | Maggie MayPlace 75 · Grade 11 · Francis Howell | 11 | Francis Howell | 22:37.62 | 51 |
| 76 | Erin IhrigPlace 76 · Grade 10 · Francis Howell | 10 | Francis Howell | 22:38.65 | 52 |
| 77 | Aubrey KaupasPlace 77 · Grade 9 · Timberland | 9 | Timberland | 22:45.34 | 53 |
| 78 | Audrey ZanderPlace 78 · Grade 10 · Francis Howell | 10 | Francis Howell | 22:46.37 | 54 |
| 79 | Lainey BusateriPlace 79 · Grade 10 · Timberland | 10 | Timberland | 22:49.92 | 55 |
| 80 | Olivia GuffeyPlace 80 · Grade 11 · Liberty (W.) | 11 | Liberty (W.) | 23:19.35 | 56 |
