| 1 | Yuri MALONEPlace 1 · Grade FR · Metro | FR | Metro | 22:15.0 |
| 2 | Katherine DOYLEPlace 2 · Grade SO · The Fulton School at | SO | The Fulton School at | 23:52.9 |
| 3 | Avery VANCEPlace 3 · Grade JR · Collegiate School of | JR | Collegiate School of | 25:29.8 |
| 4 | Viviette LINDONPlace 4 · Grade FR · Collegiate School of | FR | Collegiate School of | 25:59.1 |
| 5 | Zhakeya HAWKINSPlace 5 · Grade SO · East St. Louis (Seni | SO | East St. Louis (Seni | 26:16.2 |
| 6 | Alice KOVARIKPlace 6 · Grade SO · Metro | SO | Metro | 26:50.6 |
| 7 | Sidney HUFFPlace 7 · Grade JR · Metro | JR | Metro | 26:51.2 |
| 8 | Liana JONESPlace 8 · Grade SR · Metro | SR | Metro | 27:40.5 |
| 9 | Miranda KOVARIKPlace 9 · Grade SR · Metro | SR | Metro | 27:57.3 |
| 10 | Emily GAGNEPAINPlace 10 · Grade SO · Ursuline Academy | SO | Ursuline Academy | 28:27.0 |
| 11 | Mia NICOLETTIPlace 11 · Grade SO · Ursuline Academy | SO | Ursuline Academy | 28:58.1 |
| 12 | Theresa SANCHEZPlace 12 · Grade JR · Ursuline Academy | JR | Ursuline Academy | 29:08.4 |
| 13 | Amelia SMITHPlace 13 · Grade FR · Collegiate School of | FR | Collegiate School of | 29:28.3 |
| 14 | Sydney SMITHPlace 14 · Grade SR · Collegiate School of | SR | Collegiate School of | 30:38.7 |
| 15 | Jocelyn ARCHIEPlace 15 · Grade SR · Hazelwood East High | SR | Hazelwood East High | 30:53.8 |
| 16 | Olivia FINLEYPlace 16 · Grade FR · Metro | FR | Metro | 31:43.9 |
| 17 | Dazijah AMMONSPlace 17 · Grade SO · Miller Career Academ | SO | Miller Career Academ | 31:47.1 |
| 18 | Haley FRIGERIOPlace 18 · Grade SR · Ursuline Academy | SR | Ursuline Academy | 32:09.3 |
| 19 | Heidi FOXPlace 19 · Grade SR · Ursuline Academy | SR | Ursuline Academy | 32:57.9 |
| 20 | Brenay SMITHPlace 20 · Grade SR · East St. Louis (Seni | SR | East St. Louis (Seni | 34:48.6 |
| 21 | Armani BINGHAMPlace 21 · Grade SO · Miller Career Academ | SO | Miller Career Academ | 35:12.4 |
| 22 | Kelsey HARRISPlace 22 · Grade SR · Miller Career Academ | SR | Miller Career Academ | 35:23.3 |
| 23 | Kaitlyn THORNBERRYPlace 23 · Grade FR · Ursuline Academy | FR | Ursuline Academy | 35:57.3 |
| 24 | Stefania YOUNGERPlace 24 · Grade JR · Ursuline Academy | JR | Ursuline Academy | 36:25.0 |
| 25 | Ambrasha LAMPLEYPlace 25 · Grade SO · East St. Louis (Seni | SO | East St. Louis (Seni | 41:12.6 |
| 26 | Bailey GRAHAMPlace 26 · Grade SO · East St. Louis (Seni | SO | East St. Louis (Seni | 41:13.9 |
| 27 | Samerrea BYNUMPlace 27 · Grade JR · Miller Career Academ | JR | Miller Career Academ | 42:08.5 |
| 28 | Catherine JOHNSONPlace 28 · Grade FR · Gateway Academy | FR | Gateway Academy | 42:24.2 |
| 29 | Kyelle MCLAURINPlace 29 · Grade JR · Miller Career Academ | JR | Miller Career Academ | 45:18.8 |
| 30 | Jastice HURSTPlace 30 · Grade FR · Vashon | FR | Vashon | 46:18.0 |
| 31 | Dorietha REDMONPlace 31 · Grade FR · East St. Louis (Seni | FR | East St. Louis (Seni | 46:22.5 |
| 32 | Jamicha BROWNPlace 32 · Grade FR · Vashon | FR | Vashon | 46:49.7 |
| 33 | Dyonna MOOREPlace 33 · Grade SO · Vashon | SO | Vashon | 46:56.8 |
| 34 | Cecelia SCIACCIOPlace 34 · Grade FR · Soldan International | FR | Soldan International | 47:29.3 |
