| 1 | Zena El FarissiPlace 1 · Grade 9 · Ft. Zumwalt East | 9 | Ft. Zumwalt East | 21:02.25 PR |
| 2 | Sophia HelfrichPlace 2 · Grade 12 · Alton | 12 | Alton | 21:29.46 |
| 3 | Amelia JumperPlace 3 · Grade 9 · Jerseyville (Jersey) | 9 | Jerseyville (Jersey) | 21:36.83 |
| 4 | Sabrina EcclesPlace 4 · Grade 10 · Alton (Marquette) | 10 | Alton (Marquette) | 21:38.39 |
| 5 | Monica KlockenkemperPlace 5 · Grade 12 · Alton | 12 | Alton | 21:50.05 |
| 6 | Carly KolesarPlace 6 · Grade 9 · Staunton | 9 | Staunton | 22:08.58 |
| 7 | Aliyah RehlingPlace 7 · Grade 12 · Alton | 12 | Alton | 22:53.34 |
| 8 | Allison PruittPlace 8 · Grade 11 · Alton | 11 | Alton | 23:09.60 |
| 9 | Kylie SanchezPlace 9 · Grade 10 · Belleville (West) | 10 | Belleville (West) | 23:13.47 |
| 10 | Taylor WoodringPlace 10 · Grade 12 · Jerseyville (Jersey) | 12 | Jerseyville (Jersey) | 23:28.23 |
| 11 | Kailee WilliamsPlace 11 · Grade 12 · Belleville (West) | 12 | Belleville (West) | 23:40.80 |
| 12 | Gracie KingPlace 12 · Grade 11 · Ft. Zumwalt East | 11 | Ft. Zumwalt East | 23:44.93 PR |
| 13 | Courtney BredenPlace 13 · Grade 10 · Jerseyville (Jersey) | 10 | Jerseyville (Jersey) | 24:02.51 |
| 14 | Lucy SeneczynPlace 14 · Grade 10 · Belleville (West) | 10 | Belleville (West) | 24:24.48 |
| 15 | Isabella ChenaultPlace 15 · Grade 10 · Belleville (West) | 10 | Belleville (West) | 24:37.02 |
| 16 | Morgan JinksPlace 16 · Grade 12 · Alton | 12 | Alton | 25:02.44 |
| 17 | Andie AlfordPlace 17 · Grade 12 · Belleville (West) | 12 | Belleville (West) | 25:09.70 PR |
| 18 | Luxie GerhardtPlace 18 · Grade 9 · Staunton | 9 | Staunton | 25:10.01 |
| 19 | Belle PeuterbaughPlace 19 · Grade 12 · Jerseyville (Jersey) | 12 | Jerseyville (Jersey) | 25:19.01 |
| 20 | Sophie ConradPlace 20 · Grade 10 · Ursuline Academy | 10 | Ursuline Academy | 25:19.03 PR |
| 21 | Caroline CardinalPlace 21 · Grade 9 · Alton (Marquette) | 9 | Alton (Marquette) | 25:35.43 |
| 22 | Jaylah HarrisPlace 22 · Grade 12 · Collinsville | 12 | Collinsville | 25:38.31 |
| 23 | Elsah ClarkPlace 23 · Grade 12 · Staunton | 12 | Staunton | 25:39.76 |
| 24 | Anna CaughranPlace 24 · Grade 10 · Alton | 10 | Alton | 25:44.59 |
| 25 | Lillian HanniganPlace 25 · Grade 11 · Alton (Marquette) | 11 | Alton (Marquette) | 25:47.76 |
| 26 | Roanna NewtonPlace 26 · Grade 10 · Jerseyville (Jersey) | 10 | Jerseyville (Jersey) | 25:55.04 |
| 27 | Peyton MernickPlace 27 · Grade 9 · Belleville (West) | 9 | Belleville (West) | 26:00.20 |
| 28 | Abigail TodtPlace 28 · Grade 10 · Ursuline Academy | 10 | Ursuline Academy | 26:01.23 PR |
| 29 | Vidalia BrownPlace 29 · Grade 9 · Ft. Zumwalt East | 9 | Ft. Zumwalt East | 26:06.49 PR |
| 30 | Shalom BillupsPlace 30 · Grade 11 · Ft. Zumwalt East | 11 | Ft. Zumwalt East | 26:07.10 PR |
| 31 | Ariana DavidsonPlace 31 · Grade 12 · Ft. Zumwalt East | 12 | Ft. Zumwalt East | 26:24.15 PR |
| 32 | Katherine FitzgeraldPlace 32 · Grade 9 · Alton (Marquette) | 9 | Alton (Marquette) | 26:29.15 |
| 33 | Colette MannsPlace 33 · Grade 9 · Alton (Marquette) | 9 | Alton (Marquette) | 26:31.04 |
| 34 | Fortune AbayomiPlace 34 · Grade 10 · Belleville (West) | 10 | Belleville (West) | 26:34.87 |
| 35 | Olivia MatesaPlace 35 · Grade 12 · Staunton | 12 | Staunton | 26:36.30 |
| 36 | Isabel StabinskyPlace 36 · Grade 9 · Alton (Marquette) | 9 | Alton (Marquette) | 26:41.19 |
| 37 | Jerra VanausdollPlace 37 · Grade 11 · Jerseyville (Jersey) | 11 | Jerseyville (Jersey) | 26:51.69 |
| 38 | Ivana TorresPlace 38 · Grade 9 · Collinsville | 9 | Collinsville | 27:40.37 |
| 39 | Esme MaloPlace 39 · Grade 9 · Collinsville | 9 | Collinsville | 27:41.52 |
| 40 | Jazmine MoncelliPlace 40 · Grade 12 · Cahokia | 12 | Cahokia | 28:12.38 |
| 41 | Grace FischerPlace 41 · Grade 11 · Alton (Marquette) | 11 | Alton (Marquette) | 28:33.81 |
| 42 | Cheyenne ButcherPlace 42 · Grade 12 · Staunton | 12 | Staunton | 28:56.42 |
| 43 | Arianna SuggsPlace 43 · Grade 12 · Cahokia | 12 | Cahokia | 28:59.57 |
| 44 | Abbie MayfieldPlace 44 · Grade 9 · Staunton | 9 | Staunton | 29:00.10 |
| 45 | Jessica GabrielPlace 45 · Grade 12 · Alton | 12 | Alton | 29:19.11 |
| 46 | Malina SimmonsPlace 46 · Grade 11 · Cahokia | 11 | Cahokia | 29:31.29 |
| 47 | Nuria MorollonPlace 47 · Grade 10 · Jerseyville (Jersey) | 10 | Jerseyville (Jersey) | 29:39.96 |
| 48 | ZyAirra HoltPlace 48 · Grade 12 · Cahokia | 12 | Cahokia | 31:45.17 |
| 49 | Dakota BellPlace 49 · Grade 10 · Cahokia | 10 | Cahokia | 31:45.30 |
| 50 | Aalana RadleyPlace 50 · Grade 12 · Cahokia | 12 | Cahokia | 36:43.07 |
