| 1 | Gianna StassiPlace 1 · Grade 11 · Roxana | 11 | Roxana | 18:22.51 |
| 2 | Claire SkaffPlace 2 · Grade 9 · Belleville (Althoff Catholic) | 9 | Belleville (Althoff Catholic) | 18:29.47 PR |
| 3 | Nova ShawPlace 3 · Grade 9 · Roxana | 9 | Roxana | 18:52.95 |
| 4 | Breigh DesmondPlace 4 · Grade 11 · Belleville (Althoff Catholic) | 11 | Belleville (Althoff Catholic) | 19:21.83 |
| 5 | Camryn WheelerPlace 5 · Grade 9 · Breese (Mater Dei) | 9 | Breese (Mater Dei) | 19:28.94 |
| 6 | Lucy DoylePlace 6 · Grade 10 · Edwardsville (Metro-East Lutheran) | 10 | Edwardsville (Metro-East Lutheran) | 19:31.96 |
| 7 | Faith JansenPlace 7 · Grade 9 · Belleville (Althoff Catholic) | 9 | Belleville (Althoff Catholic) | 19:43.41 PR |
| 8 | Finley HaagPlace 8 · Grade 11 · Breese (Mater Dei) | 11 | Breese (Mater Dei) | 19:47.05 |
| 9 | Addison DurbinPlace 9 · Grade 10 · Lebanon | 10 | Lebanon | 19:54.66 |
| 10 | Emeri SagerPlace 10 · Grade 10 · Fairfield | 10 | Fairfield | 19:57.01 |
| 11 | Grace JansenPlace 11 · Grade 10 · Belleville (Althoff Catholic) | 10 | Belleville (Althoff Catholic) | 20:00.41 |
| 12 | Emma DiekemperPlace 12 · Grade 12 · Breese (Mater Dei) | 12 | Breese (Mater Dei) | 20:14.71 |
| 13 | Ainsley TurkingtonPlace 13 · Grade 11 · Glen Carbon (Father McGivney) | 11 | Glen Carbon (Father McGivney) | 20:16.20 |
| 14 | Bella RedeniusPlace 14 · Grade 11 · Glen Carbon (Father McGivney) | 11 | Glen Carbon (Father McGivney) | 20:16.73 |
| 15 | McKenzie JonesPlace 15 · Grade 11 · Glen Carbon (Father McGivney) | 11 | Glen Carbon (Father McGivney) | 20:22.73 |
| 16 | Adi HickeyPlace 16 · Grade 12 · Fairfield | 12 | Fairfield | 20:30.24 |
| 17 | Reagan NapovanicePlace 17 · Grade 12 · Breese (Mater Dei) | 12 | Breese (Mater Dei) | 20:35.97 |
| 18 | Katelin HuelsmannPlace 18 · Grade 9 · Breese (Mater Dei) | 9 | Breese (Mater Dei) | 20:36.08 |
| 19 | Marion HemmerPlace 19 · Grade 10 · Edwardsville (Metro-East Lutheran) | 10 | Edwardsville (Metro-East Lutheran) | 20:43.58 PR |
| 20 | Carly KolesarPlace 20 · Grade 9 · Staunton | 9 | Staunton | 20:45.15 |
| 21 | Elizabeth ClousePlace 21 · Grade 11 · Roxana | 11 | Roxana | 20:54.51 |
| 22 | Savannah ClinePlace 22 · Grade 9 · Roxana | 9 | Roxana | 20:54.97 |
| 23 | Jaycie CouchPlace 23 · Grade 12 · Fairfield | 12 | Fairfield | 20:55.23 |
| 24 | Bailey Schallenberg-DeckerPlace 24 · Grade 11 · Roxana | 11 | Roxana | 20:57.33 |
| 25 | Ava LockPlace 25 · Grade 11 · Belleville (Althoff Catholic) | 11 | Belleville (Althoff Catholic) | 20:57.50 |
| 26 | Tania RivasPlace 26 · Grade 12 · Dupo | 12 | Dupo | 21:03.54 |
| 27 | Brianna MeeksPlace 27 · Grade 10 · Fairfield | 10 | Fairfield | 21:20.12 |
| 28 | Reid EmigPlace 28 · Grade 12 · Breese (Mater Dei) | 12 | Breese (Mater Dei) | 21:44.83 |
| 29 | Remington TaylorPlace 29 · Grade 11 · Fairfield | 11 | Fairfield | 21:48.87 |
| 30 | Mallory LucykowPlace 30 · Grade 12 · Staunton | 12 | Staunton | 21:52.62 |
| 31 | Ellanie VanwayPlace 31 · Grade 11 · Fairfield | 11 | Fairfield | 21:55.17 |
| 32 | Luxie GerhardtPlace 32 · Grade 9 · Staunton | 9 | Staunton | 22:00.07 PR |
| 33 | Ashtyn WheelerPlace 33 · Grade 12 · Breese (Mater Dei) | 12 | Breese (Mater Dei) | 22:07.14 |
| 34 | Gabby ZurlienePlace 34 · Grade 10 · Fairfield | 10 | Fairfield | 22:08.50 |
| 35 | Moira KruegerPlace 35 · Grade 10 · Edwardsville (Metro-East Lutheran) | 10 | Edwardsville (Metro-East Lutheran) | 22:08.94 |
| 36 | Miley BadgettPlace 36 · Grade 10 · Glen Carbon (Father McGivney) | 10 | Glen Carbon (Father McGivney) | 22:15.23 |
| 37 | Madelyn NordikePlace 37 · Grade 12 · Trenton (Wesclin) | 12 | Trenton (Wesclin) | 22:18.78 |
| 38 | Bethany KeePlace 38 · Grade 11 · Belleville (Althoff Catholic) | 11 | Belleville (Althoff Catholic) | 22:20.20 |
| 39 | Anna MoorePlace 39 · Grade 10 · Glen Carbon (Father McGivney) | 10 | Glen Carbon (Father McGivney) | 22:21.30 PR |
| 40 | Addison AllenPlace 40 · Grade 10 · Lebanon | 10 | Lebanon | 22:38.72 PR |
| 41 | Lily WallochPlace 41 · Grade 10 · Edwardsville (Metro-East Lutheran) | 10 | Edwardsville (Metro-East Lutheran) | 22:43.80 |
| 42 | Arabella SumnlersPlace 42 · Grade 10 · Glen Carbon (Father McGivney) | 10 | Glen Carbon (Father McGivney) | 22:52.82 |
| 43 | Abigail (Abby) AyerPlace 43 · Grade 10 · Edwardsville (Metro-East Lutheran) | 10 | Edwardsville (Metro-East Lutheran) | 22:57.00 |
| 44 | McCulloch MillerPlace 44 · Grade 10 · Dupo | 10 | Dupo | 23:01.27 |
| 45 | Mackenzie MinnerPlace 45 · Grade 10 · Wood River (East Alton-W.R.) | 10 | Wood River (East Alton-W.R.) | 23:29.54 |
| 46 | Elsah ClarkPlace 46 · Grade 12 · Staunton | 12 | Staunton | 23:36.44 |
| 47 | Lydia LaRosaPlace 47 · Grade 11 · Staunton | 11 | Staunton | 23:41.39 |
| 48 | Olivia MatesaPlace 48 · Grade 12 · Staunton | 12 | Staunton | 23:45.48 |
| 49 | Ava VenhausPlace 49 · Grade 11 · Trenton (Wesclin) | 11 | Trenton (Wesclin) | 23:52.92 |
| 50 | Keeley ShoemakerPlace 50 · Grade 11 · Piasa (Southwestern) | 11 | Piasa (Southwestern) | 23:59.13 |
| 51 | Marlena YoungmeyerPlace 51 · Grade 9 · Belleville (Althoff Catholic) | 9 | Belleville (Althoff Catholic) | 24:05.81 |
| 52 | Audrey VollintinePlace 52 · Grade 12 · Piasa (Southwestern) | 12 | Piasa (Southwestern) | 24:15.90 PR |
| 53 | Eliza SparksPlace 53 · Grade 10 · Louisville (North Clay) | 10 | Louisville (North Clay) | 24:20.56 |
| 54 | Cheyenne ButcherPlace 54 · Grade 12 · Staunton | 12 | Staunton | 25:00.13 |
| 55 | Emilia MalcombPlace 55 · Grade 10 · Edwardsville (Metro-East Lutheran) | 10 | Edwardsville (Metro-East Lutheran) | 25:22.15 PR |
| 56 | Brooke DiveleyPlace 56 · Grade 11 · Dupo | 11 | Dupo | 25:27.74 |
| 57 | Savannah PontiousPlace 57 · Grade 11 · Lebanon | 11 | Lebanon | 25:54.39 |
| 58 | Mia DonaldPlace 58 · Grade 12 · Maryville (M. Christian) | 12 | Maryville (M. Christian) | 26:15.14 |
| 59 | Maddie GordonPlace 59 · Grade 12 · Piasa (Southwestern) | 12 | Piasa (Southwestern) | 26:24.08 |
| 60 | Gina TruaxPlace 60 · Grade 12 · Wood River (East Alton-W.R.) | 12 | Wood River (East Alton-W.R.) | 26:32.01 |
| 61 | Keegan BrownPlace 61 · Grade 11 · Lebanon | 11 | Lebanon | 26:38.47 |
| 62 | Kaylie ConnerPlace 62 · Grade 9 · Dupo | 9 | Dupo | 26:41.65 |
| 63 | Leone BoucardPlace 63 · Grade 12 · Lebanon | 12 | Lebanon | 26:43.31 PR |
| 64 | Kaitlyn PickerellPlace 64 · Grade 11 · Edwardsville (Metro-East Lutheran) | 11 | Edwardsville (Metro-East Lutheran) | 26:51.59 |
| 65 | Ami ParsonsPlace 65 · Grade 9 · Wood River (East Alton-W.R.) | 9 | Wood River (East Alton-W.R.) | 26:54.55 |
| 66 | Izzy WhitePlace 66 · Grade 12 · Dupo | 12 | Dupo | 27:03.68 |
| 67 | Gracie LindseyPlace 67 · Grade 10 · Carlyle | 10 | Carlyle | 27:23.67 PR |
| 68 | Payton ScheitlinPlace 68 · Grade 11 · Carlyle | 11 | Carlyle | 28:08.16 |
| 69 | Gracie CurrenPlace 69 · Grade 12 · Roxana | 12 | Roxana | 28:46.23 |
| 70 | Lily StahlmanPlace 70 · Grade 12 · Trenton (Wesclin) | 12 | Trenton (Wesclin) | 33:07.58 |
