| 1 | Audrey MorrisPlace 1 · Grade 10 · Jackson | 10 | Jackson | 24:14.50 |
| 2 | Madelyn WilsonPlace 2 · Grade 12 · Northwest (Cedar Hill) | 12 | Northwest (Cedar Hill) | 24:53.58 |
| 3 | Kinley BeardPlace 3 · Grade 9 · Jackson | 9 | Jackson | 25:08.69 |
| 4 | Mia BrownPlace 4 · Grade 9 · Windsor (Imperial) | 9 | Windsor (Imperial) | 25:42.82 |
| 5 | Danica GriffinPlace 5 · Grade 10 · Northwest (Cedar Hill) | 10 | Northwest (Cedar Hill) | 26:02.73 |
| 6 | Kaylah KleffnerPlace 6 · Grade 12 · Northwest (Cedar Hill) | 12 | Northwest (Cedar Hill) | 26:09.28 |
| 7 | Emily BurrPlace 7 · Grade 9 · Northwest (Cedar Hill) | 9 | Northwest (Cedar Hill) | 26:10.50 |
| 8 | Ava MillerPlace 8 · Grade 10 · Farmington | 10 | Farmington | 26:19.52 |
| 9 | Leslie MartinPlace 9 · Grade 9 · Farmington | 9 | Farmington | 26:35.46 |
| 10 | Maya PohlmannPlace 10 · Grade 12 · Northwest (Cedar Hill) | 12 | Northwest (Cedar Hill) | 26:38.23 |
| 11 | Ava GrindellPlace 11 · Grade 10 · Windsor (Imperial) | 10 | Windsor (Imperial) | 27:10.27 |
| 12 | Parker NicholsonPlace 12 · Grade 9 · Farmington | 9 | Farmington | 27:27.17 |
| 13 | Emma SlavenPlace 13 · Grade 11 · Mehlville | 11 | Mehlville | 27:31.65 |
| 14 | Audri ArjonaPlace 14 · Grade 9 · Senath-Hornersville | 9 | Senath-Hornersville | 27:45.58 |
| 15 | Grace DunningPlace 15 · Grade 11 · Advance | 11 | Advance | 27:47.43 |
| 16 | Chloe LammertPlace 16 · Grade 12 · Windsor (Imperial) | 12 | Windsor (Imperial) | 28:06.31 |
| 17 | Alisyn SimpsonPlace 17 · Grade 11 · Bernie | 11 | Bernie | 28:06.45 |
| 18 | Maleyah MorrowPlace 18 · Grade 10 · Mehlville | 10 | Mehlville | 28:38.44 |
| 19 | Evelyn DewrockPlace 19 · Grade 10 · Central (Cape Girardeau) | 10 | Central (Cape Girardeau) | 29:22.23 |
| 20 | Aubree BrawleyPlace 20 · Grade 10 · Scott City | 10 | Scott City | 29:22.90 |
| 21 | Maycen JarrettPlace 21 · Grade 9 · Central (Cape Girardeau) | 9 | Central (Cape Girardeau) | 29:32.07 |
| 22 | Kelcei WalterPlace 22 · Grade 9 · Farmington | 9 | Farmington | 29:38.33 |
| 23 | Alison MickaPlace 23 · Grade 9 · Mehlville | 9 | Mehlville | 29:40.52 |
| 24 | Sherry ChenPlace 24 · Grade 9 · Jackson | 9 | Jackson | 30:11.65 |
| 25 | Hattie VersemannPlace 25 · Grade 10 · Jackson | 10 | Jackson | 30:35.48 |
| 26 | Melanie BarkerPlace 26 · Grade 11 · Mehlville | 11 | Mehlville | 30:35.77 |
| 27 | Kenna DemarestPlace 27 · Grade 9 · Jackson | 9 | Jackson | 30:44.03 |
| 28 | Abbie JohnsonPlace 28 · Grade 10 · Kelly | 10 | Kelly | 31:46.87 |
| 29 | Sofia TurnerPlace 29 · Grade 10 · Jackson | 10 | Jackson | 32:30.16 |
| 30 | Grace SeyerPlace 30 · Grade 9 · Notre Dame (Cape Girardeau) | 9 | Notre Dame (Cape Girardeau) | 32:37.86 |
| 31 | Gemma MeyerPlace 31 · Grade 12 · Mehlville | 12 | Mehlville | 32:46.27 |
| 32 | Samantha PuchbauerPlace 32 · Grade 9 · Jackson | 9 | Jackson | 32:49.78 |
| 33 | Greta DittmerPlace 33 · Grade 10 · Notre Dame (Cape Girardeau) | 10 | Notre Dame (Cape Girardeau) | 32:56.55 |
| 34 | Ramyiah McNairPlace 34 · Grade 9 · Bloomfield | 9 | Bloomfield | 33:09.97 |
| 35 | Kelsi BerkbueglerPlace 35 · Grade 9 · Notre Dame (Cape Girardeau) | 9 | Notre Dame (Cape Girardeau) | 33:12.76 |
| 36 | Isabelle WilsonPlace 36 · Grade 11 · Central (Cape Girardeau) | 11 | Central (Cape Girardeau) | 33:15.63 |
| 37 | Becky CastilloPlace 37 · Grade 9 · Kelly | 9 | Kelly | 33:53.81 |
| 38 | Elizabeth HillPlace 38 · Grade 12 · Anna (A.-Jonesboro) | 12 | Anna (A.-Jonesboro) | 35:07.21 |
| 39 | Makaila GoettePlace 39 · Grade 9 · Northwest (Cedar Hill) | 9 | Northwest (Cedar Hill) | 35:19.71 |
| 40 | Keira TimmonsPlace 40 · Grade 11 · Windsor (Imperial) | 11 | Windsor (Imperial) | 36:48.73 |
| 41 | Emma WatsonPlace 41 · Grade 12 · Farmington | 12 | Farmington | 36:58.57 |
| 42 | Shauna CarrollPlace 42 · Grade 10 · Farmington | 10 | Farmington | 37:15.72 |
| 43 | Charly GentryPlace 43 · Grade 9 · Jackson | 9 | Jackson | 42:46.78 |
| 44 | Magda MartinezPlace 44 · Grade 10 · Senath-Hornersville | 10 | Senath-Hornersville | 49:38.54 |
| — | Angela LedezmaGrade 10 · Senath-Hornersville | 10 | Senath-Hornersville | DQ |
