| 1 | Makensie GEEPlace 1 · Grade 10 · Crystal City | 10 | Crystal City | 23:36.9 |
| 2 | Ella KuhnPlace 2 · Grade 10 · North Point | 10 | North Point | 25:11.9 |
| 3 | Reagan SimlerPlace 3 · Grade 9 · North Point | 9 | North Point | 25:13.6 |
| 4 | Shelby WicklundPlace 4 · Grade 9 · North Point | 9 | North Point | 25:18.0 |
| 5 | Ella LangnerPlace 5 · Grade 10 · North Point | 10 | North Point | 25:24.7 |
| 6 | Audri ArjonaPlace 6 · Grade 9 · Senath-Hornersville | 9 | Senath-Hornersville | 25:31.9 |
| 7 | Jossalyn WalkerPlace 7 · Grade 10 · St. Pius X (Festus) | 10 | St. Pius X (Festus) | 25:36.7 |
| 8 | Holly LafavePlace 8 · Grade 11 · North Point | 11 | North Point | 25:58.1 |
| 9 | Ashlyn CrainPlace 9 · Grade 9 · Meadow Heights | 9 | Meadow Heights | 26:02.0 |
| 10 | Kenslee LathamPlace 10 · Grade 11 · Zalma | 11 | Zalma | 26:04.2 PR |
| 11 | Taylor ColemanPlace 11 · Grade 12 · Campbell | 12 | Campbell | 26:13.8 |
| 12 | Lola LongPlace 12 · Grade 9 · Fredericktown | 9 | Fredericktown | 26:21.8 |
| 13 | Susannah WheelerPlace 13 · Grade 10 · Campbell | 10 | Campbell | 26:30.0 |
| 14 | Grace BuchheitPlace 14 · Grade 10 · Perryville | 10 | Perryville | 26:44.5 PR |
| 15 | Grace DiebelPlace 15 · Grade 12 · North Point | 12 | North Point | 26:50.3 |
| 16 | Addelynne KirnPlace 16 · Grade 10 · Perryville | 10 | Perryville | 26:56.2 |
| 17 | Esveidy Antonio GarciaPlace 17 · Grade 10 · Perryville | 10 | Perryville | 27:03.1 |
| 18 | Elizabeth HannersPlace 18 · Grade 11 · Meadow Heights | 11 | Meadow Heights | 27:13.3 |
| 19 | Aryanna Lei MembrerePlace 19 · Grade 9 · North Point | 9 | North Point | 27:23.2 |
| 20 | Analeigh PeachPlace 20 · Grade 9 · Advance | 9 | Advance | 27:30.4 PR |
| 21 | Aubree BrawleyPlace 21 · Grade 10 · Scott City | 10 | Scott City | 27:43.2 |
| 22 | Kathryn RowlandPlace 22 · Grade 12 · Notre Dame (Cape Girardeau) | 12 | Notre Dame (Cape Girardeau) | 27:48.4 |
| 23 | Kiera BerryPlace 23 · Grade 9 · St. Vincent | 9 | St. Vincent | 27:50.5 |
| 24 | Alexsyn SchnurbuschPlace 24 · Grade 9 · St. Vincent | 9 | St. Vincent | 27:54.5 |
| 25 | Abbie JohnsonPlace 25 · Grade 10 · Kelly | 10 | Kelly | 27:59.8 |
| 26 | Rita-joy WheelerPlace 26 · Grade 12 · Campbell | 12 | Campbell | 28:33.6 |
| 27 | Charlotte TomlinsonPlace 27 · Grade 9 · St. Vincent | 9 | St. Vincent | 28:41.4 |
| 28 | Adalyn WhitePlace 28 · Grade 9 · Puxico | 9 | Puxico | 28:47.9 |
| 29 | Tatum FrickPlace 29 · Grade 11 · Central (Cape Girardeau) | 11 | Central (Cape Girardeau) | 29:18.2 PR |
| 30 | Journey HicksPlace 30 · Grade 9 · Advance | 9 | Advance | 29:31.7 PR |
| 31 | Saar BeerensPlace 31 · Grade 11 · North Point | 11 | North Point | 29:47.4 |
| 32 | Grace SeyerPlace 32 · Grade 9 · Notre Dame (Cape Girardeau) | 9 | Notre Dame (Cape Girardeau) | 30:00.3 |
| 33 | Evelyn MontierthPlace 33 · Grade 9 · Fredericktown | 9 | Fredericktown | 30:26.9 |
| 34 | Becky CastilloPlace 34 · Grade 9 · Kelly | 9 | Kelly | 30:33.5 PR |
| 35 | Kelsi BerkbueglerPlace 35 · Grade 9 · Notre Dame (Cape Girardeau) | 9 | Notre Dame (Cape Girardeau) | 30:38.8 |
| 36 | Christina EmmettPlace 36 · Grade 9 · St. Pius X (Festus) | 9 | St. Pius X (Festus) | 31:19.8 |
| 37 | Destiny WoodsPlace 37 · Grade 9 · Central (Cape Girardeau) | 9 | Central (Cape Girardeau) | 31:39.7 PR |
| 38 | Skylar TannerPlace 38 · Grade 9 · Puxico | 9 | Puxico | 31:42.8 PR |
| 39 | Adele RyanPlace 39 · Grade 9 · St. Vincent | 9 | St. Vincent | 31:55.5 |
| 40 | Stella AllenPlace 40 · Grade 9 · North Point | 9 | North Point | 32:32.5 PR |
| 41 | Amillyah KetchersidePlace 41 · Grade 10 · West County | 10 | West County | 32:32.5 |
| 42 | Alaina HaertlingPlace 42 · Grade 9 · St. Vincent | 9 | St. Vincent | 32:59.8 |
| 43 | McKenzie CrosePlace 43 · Grade 11 · Meadow Heights | 11 | Meadow Heights | 33:09.3 |
| 44 | Brandalynn JohnsonPlace 44 · Grade 12 · Meadow Heights | 12 | Meadow Heights | 33:31.0 |
| 45 | Ada BuersmeyerPlace 45 · Grade 10 · Notre Dame (Cape Girardeau) | 10 | Notre Dame (Cape Girardeau) | 33:43.9 |
| 46 | Kaeden SullensPlace 46 · Grade 9 · North Point | 9 | North Point | 34:18.5 |
| 47 | Annabelle OlingerPlace 47 · Grade 10 · Campbell | 10 | Campbell | 34:29.4 |
| 48 | Jenna BurgfeldPlace 48 · Grade 10 · Meadow Heights | 10 | Meadow Heights | 34:50.2 |
| 49 | Gianna DavisPlace 49 · Grade 9 · St. Pius X (Festus) | 9 | St. Pius X (Festus) | 34:51.0 |
| 50 | Ava JonesPlace 50 · Grade 11 · Campbell | 11 | Campbell | 35:26.0 PR |
| 51 | Penelope BeilPlace 51 · Grade 9 · St. Pius X (Festus) | 9 | St. Pius X (Festus) | 35:28.7 |
| 52 | Neva BrownPlace 52 · Grade 9 · St. Vincent | 9 | St. Vincent | 35:57.5 |
| 53 | Micah JoycePlace 53 · Grade 12 · Kelly | 12 | Kelly | 36:25.7 |
| 54 | Faith ChildsPlace 54 · Grade 10 · Notre Dame (Cape Girardeau) | 10 | Notre Dame (Cape Girardeau) | 36:37.0 |
| 55 | Leslie HernandezPlace 55 · Grade 10 · Notre Dame (Cape Girardeau) | 10 | Notre Dame (Cape Girardeau) | 37:25.7 |
| 56 | Lea AustinPlace 56 · Grade 10 · Central (Cape Girardeau) | 10 | Central (Cape Girardeau) | 40:19.4 |
| 57 | Angela LedezmaPlace 57 · Grade 10 · Senath-Hornersville | 10 | Senath-Hornersville | 49:18.0 |
