| 1 | Martina ResselPlace 1 · Grade 11 · Notre Dame (Cape Girardeau) | 11 | Notre Dame (Cape Girardeau) | 21:26.7 |
| 2 | Annabelle NaughtonPlace 2 · Grade 10 · Notre Dame (Cape Girardeau) | 10 | Notre Dame (Cape Girardeau) | 22:27.0 |
| 3 | Briley MeyrPlace 3 · Grade 10 · Saxony Lutheran | 10 | Saxony Lutheran | 22:33.9 |
| 4 | Jolin ZhangPlace 4 · Grade 12 · Notre Dame (Cape Girardeau) | 12 | Notre Dame (Cape Girardeau) | 22:35.2 |
| 5 | Brylee CampbellPlace 5 · Grade 9 · Puxico | 9 | Puxico | 22:58.4 |
| 6 | Victoria Avila HenaoPlace 6 · Grade 12 · Notre Dame (Cape Girardeau) | 12 | Notre Dame (Cape Girardeau) | 23:19.1 |
| 7 | Raylee MatthewsPlace 7 · Grade 12 · Saxony Lutheran | 12 | Saxony Lutheran | 23:44.8 |
| 8 | Braidy TalburtPlace 8 · Grade 9 · Doniphan | 9 | Doniphan | 23:47.7 |
| 9 | Kelsey KerperienPlace 9 · Grade 9 · Bernie | 9 | Bernie | 23:49.7 PR |
| 10 | Kinsley McGonigalPlace 10 · Grade 10 · Doniphan | 10 | Doniphan | 24:08.2 |
| 11 | Mikyla AllenPlace 11 · Grade 9 · Puxico | 9 | Puxico | 24:14.8 |
| 12 | Emmy BengtsonPlace 12 · Grade 10 · Saxony Lutheran | 10 | Saxony Lutheran | 24:37.8 |
| 13 | Peyton St. CinPlace 13 · Grade 11 · Doniphan | 11 | Doniphan | 26:58.9 |
| 14 | Lauren UpchurchPlace 14 · Grade 11 · Bloomfield | 11 | Bloomfield | 27:06.3 |
| 15 | Ally FergusonPlace 15 · Grade 9 · Poplar Bluff | 9 | Poplar Bluff | 27:30.4 |
| 16 | Faithlynn TillmanPlace 16 · Grade 10 · Naylor | 10 | Naylor | 27:55.2 |
| 17 | Peyton CarlislePlace 17 · Grade 12 · Risco | 12 | Risco | 28:16.0 |
| 18 | Keeley ReynoldsPlace 18 · Grade 12 · Poplar Bluff | 12 | Poplar Bluff | 28:45.6 |
| 19 | Abigail HicksPlace 19 · Grade 10 · Greenville | 10 | Greenville | 29:36.9 |
| 20 | Muriel BrummelPlace 20 · Grade 9 · Saxony Lutheran | 9 | Saxony Lutheran | 30:25.3 |
| 21 | Clare GarnerPlace 21 · Grade 11 · Notre Dame (Cape Girardeau) | 11 | Notre Dame (Cape Girardeau) | 30:46.1 |
| 22 | Lacey GibsonPlace 22 · Grade 11 · Clearwater | 11 | Clearwater | 31:04.2 |
| 23 | Maggie BuchheitPlace 23 · Grade 11 · Notre Dame (Cape Girardeau) | 11 | Notre Dame (Cape Girardeau) | 31:04.7 |
| 24 | Bellah MyersPlace 24 · Grade 9 · Naylor | 9 | Naylor | 31:14.1 |
| 25 | Jasa GilleanPlace 25 · Grade 12 · Naylor | 12 | Naylor | 31:27.7 |
| 26 | Olivia PetzoldtPlace 26 · Grade 11 · Saxony Lutheran | 11 | Saxony Lutheran | 31:30.1 |
| 27 | Emma KovachPlace 27 · Grade 9 · Doniphan | 9 | Doniphan | 32:37.7 |
| 28 | Mallorie HowardPlace 28 · Grade 11 · Greenville | 11 | Greenville | 33:21.4 |
| 29 | Megan BirkPlace 29 · Grade 12 · Saxony Lutheran | 12 | Saxony Lutheran | 33:32.7 |
| 30 | Susana GarciaPlace 30 · Grade 11 · Senath-Hornersville | 11 | Senath-Hornersville | 34:14.0 |
| 31 | Averi RainwaterPlace 31 · Grade 10 · Greenville | 10 | Greenville | 34:30.9 |
| 32 | Skylar TannerPlace 32 · Grade 9 · Puxico | 9 | Puxico | 34:33.9 |
| 33 | Hanna ConnerPlace 33 · Grade 10 · Richland (Essex) | 10 | Richland (Essex) | 35:32.1 |
| 34 | Amelia SmithPlace 34 · Grade 12 · Kennett | 12 | Kennett | 35:59.3 |
| 35 | Taylor HeinleyPlace 35 · Grade 12 · Kennett | 12 | Kennett | 36:12.9 |
| 36 | Avery PaynePlace 36 · Grade 12 · Kennett | 12 | Kennett | 37:18.6 |
| 37 | Payton BuhlerPlace 37 · Grade 9 · Naylor | 9 | Naylor | 39:42.4 |
| 38 | Brailee ArnoldPlace 38 · Grade 10 · Naylor | 10 | Naylor | 40:01.1 |
| 39 | Claudia DavisPlace 39 · Grade 10 · Greenville | 10 | Greenville | 40:01.3 |
