| 1 | Rokel SandersPlace 1 · Grade 12 · Wilson | 12 | Wilson | 22:48.4 |
| 2 | Jubilee LEIPlace 2 · Grade 9 · Trinity Collegiate | 9 | Trinity Collegiate | 22:51.8 |
| 3 | Natalie FergusonPlace 3 · St.AnthonyCatholic | — | St.AnthonyCatholic | 23:20.8 |
| 4 | Stary SamuelPlace 4 · Grade 12 · Wilson | 12 | Wilson | 24:54.0 |
| 5 | Hayden RobinsonPlace 5 · Grade 12 · Wilson | 12 | Wilson | 24:58.1 |
| 6 | Mary Sullivan-PowellPlace 6 · Grade 7 · Thomas Hart Academy | 7 | Thomas Hart Academy | 25:05.1 |
| 7 | Zoey CopelandPlace 7 · Grade 9 · Central | 9 | Central | 25:22.5 |
| 8 | Camdyn OsteenPlace 8 · Grade 10 · Sumter | 10 | Sumter | 25:47.0 |
| 9 | Shakira EppsPlace 9 · Grade 10 · Wilson | 10 | Wilson | 25:54.1 |
| 10 | Ry'leigh MorrisPlace 10 · Grade 8 · Lamar | 8 | Lamar | 26:21.2 |
| 11 | Maylee BrownPlace 11 · Grade 9 · South Florence | 9 | South Florence | 26:33.3 |
| 12 | Parris MaddoxPlace 12 · Grade 11 · Central | 11 | Central | 26:35.4 |
| 13 | Mackenzie SturkiePlace 13 · Grade 7 · Lamar | 7 | Lamar | 26:49.2 |
| 14 | Mattie KellyPlace 14 · Grade 12 · East Clarendon | 12 | East Clarendon | 26:57.3 |
| 15 | Stokes FieldsPlace 15 · Grade 10 · South Florence | 10 | South Florence | 27:00.3 |
| 16 | Jessica GrahamPlace 16 · Grade 11 · Lake City | 11 | Lake City | 27:05.3 |
| 17 | Evelyn Garcia-TorresPlace 17 · St.AnthonyCatholic | — | St.AnthonyCatholic | 27:08.8 |
| 18 | Gabby MendiolaPlace 18 · Grade 12 · Lamar | 12 | Lamar | 27:37.5 |
| 19 | Ava TynerPlace 19 · Grade 11 · South Florence | 11 | South Florence | 28:26.6 |
| 20 | Arleigh KingPlace 20 · Grade - · Trinity Collegiate | - | Trinity Collegiate | 28:33.8 |
| 21 | Anna FelkelPlace 21 · Grade - · Trinity Collegiate | - | Trinity Collegiate | 28:34.8 |
| 22 | Graycee DuncanPlace 22 · Grade 12 · Marlboro County | 12 | Marlboro County | 29:23.0 |
| 23 | Autumn ShepherdPlace 23 · Grade 11 · Marlboro County | 11 | Marlboro County | 29:51.9 PR |
| 24 | Caroline FelkelPlace 24 · Grade - · Trinity Collegiate | - | Trinity Collegiate | 30:34.0 |
| 25 | Taylor KinlawPlace 25 · Grade 7 · Wilson | 7 | Wilson | 30:39.9 |
| 26 | Lilly PhilipsheckPlace 26 · Grade 10 · Central | 10 | Central | 30:40.8 |
| 27 | Amelia SteinmetzPlace 27 · Grade 12 · South Florence | 12 | South Florence | 31:06.7 |
| 28 | Crosbie HugginsPlace 28 · St.AnthonyCatholic | — | St.AnthonyCatholic | 31:07.7 |
| 29 | De'Arria HannaPlace 29 · Grade - · Lake City | - | Lake City | 31:35.0 PR |
| 30 | Vanessa BetancourtPlace 30 · Grade 9 · Dillon | 9 | Dillon | 32:00.0 |
| 31 | Katie MoselyPlace 31 · Grade - · Central | - | Central | 32:22.5 PR |
| 32 | Chole McConnellPlace 32 · Grade 11 · Crestwood | 11 | Crestwood | 32:30.1 |
| 33 | Alaia BrownPlace 33 · Grade 12 · Marlboro County | 12 | Marlboro County | 32:34.1 |
| 34 | Frink JaylaPlace 34 · Grade 12 · East Clarendon | 12 | East Clarendon | 32:36.5 |
| 35 | Makayla MarcumPlace 35 · Grade 12 · Sumter | 12 | Sumter | 32:39.6 |
| 36 | Sabrina ShockeyPlace 36 · St.AnthonyCatholic | — | St.AnthonyCatholic | 32:40.0 |
| 37 | Amaris BurnesPlace 37 · Grade 7 · Wilson | 7 | Wilson | 32:43.5 |
| 38 | Isabella NarvaezPlace 38 · St.AnthonyCatholic | — | St.AnthonyCatholic | 34:20.1 |
| 39 | Audrey SowellPlace 39 · Grade 8 · Lamar | 8 | Lamar | 34:48.4 |
| 40 | Danna Lucas-ZalazarPlace 40 · Grade 11 · Central | 11 | Central | 34:58.5 PR |
| 41 | Peyton ButlerPlace 41 · Grade 10 · Dillon | 10 | Dillon | 35:09.9 |
| 42 | Ryley ColePlace 42 · Grade - · Trinity Collegiate | - | Trinity Collegiate | 35:13.6 PR |
| 43 | Jenasys JacksonPlace 43 · Grade 12 · Wilson | 12 | Wilson | 35:14.1 |
| 44 | Ashley MerinoPlace 44 · Grade - · Central | - | Central | 35:19.2 PR |
| 45 | Abigail BrewerPlace 45 · Grade 9 · South Florence | 9 | South Florence | 35:20.0 |
| 46 | Nevaeh WhitePlace 46 · Grade - · Dillon | - | Dillon | 35:29.8 PR |
| 47 | Savannah GaineyPlace 47 · Grade 6 · Thomas Hart Academy | 6 | Thomas Hart Academy | 35:58.3 |
| 48 | Aaliyah AlfredPlace 48 · Grade 11 · Marlboro County | 11 | Marlboro County | 36:41.6 PR |
| 49 | Kensi TunnellPlace 49 · Grade 6 · Thomas Hart Academy | 6 | Thomas Hart Academy | 36:43.7 |
| 50 | De'Jorrien HannaPlace 50 · Grade 10 · Lake City | 10 | Lake City | 37:21.2 |
| 51 | Naadyia ReesePlace 51 · Grade 12 · Dillon | 12 | Dillon | 37:27.7 |
| 52 | Lyric TownsendPlace 52 · Grade 9 · Dillon | 9 | Dillon | 37:56.5 |
| 53 | Phoenix LilleyPlace 53 · Grade 10 · Lamar | 10 | Lamar | 37:58.0 |
| 54 | Zien GunterPlace 54 · Grade 12 · Lake City | 12 | Lake City | 38:08.6 PR |
| 55 | Alana McManusPlace 55 · Grade 8 · Marlboro County | 8 | Marlboro County | 38:22.3 PR |
| 56 | Maddie KirbyPlace 56 · Grade 8 · East Clarendon | 8 | East Clarendon | 38:32.2 |
| 57 | Haya GhalayiniPlace 57 · St.AnthonyCatholic | — | St.AnthonyCatholic | 38:32.8 |
| 58 | Janiya SpatesPlace 58 · Grade - · Lake City | - | Lake City | 39:36.4 PR |
| 59 | Sueling MoseleyPlace 59 · Grade 11 · Central | 11 | Central | 40:13.4 |
| 60 | Amelia BrancatoPlace 60 · Grade 12 · East Clarendon | 12 | East Clarendon | 40:22.8 PR |
| 61 | Tiana PolancoPlace 61 · Grade 11 · Crestwood | 11 | Crestwood | 40:49.2 |
| 62 | Isabelle BittlePlace 62 · Grade 11 · Marlboro County | 11 | Marlboro County | 42:56.5 |
| 63 | Carrie ElvisPlace 63 · Grade 9 · East Clarendon | 9 | East Clarendon | 43:24.7 |
| 64 | Kailtlyn FreemanPlace 64 · Grade - · Marlboro County | - | Marlboro County | 44:47.1 PR |
| 65 | Shermiya JohnsonPlace 65 · Grade 10 · Crestwood | 10 | Crestwood | 46:27.6 PR |
| 66 | Janiya EppsPlace 66 · Grade 11 · Wilson | 11 | Wilson | 46:33.9 |
| 67 | Tyerra ParksPlace 67 · Grade - · Central | - | Central | 47:54.2 PR |
| 68 | Ximana SanchezPlace 68 · Grade - · Central | - | Central | 50:51.7 PR |
