| 1 | Ellen ToenniesPlace 1 · Mater Dei | — | Mater Dei | 19:25.00 | 1 |
| 2 | Madeline LagerPlace 2 · Mater Dei | — | Mater Dei | 19:26.00 | 2 |
| 3 | Annika SissonPlace 3 · Parkway Central | — | Parkway Central | 19:57.00 | 3 |
| 4 | Bailey GeorgePlace 4 · Mater Dei | — | Mater Dei | 20:00.00 | 4 |
| 5 | Kourtney HuelskampPlace 5 · Mater Dei | — | Mater Dei | 20:04.00 | 5 |
| 6 | Taylore BurkePlace 6 · Parkway Central | — | Parkway Central | 20:13.00 | 6 |
| 7 | Sarah PollmannPlace 7 · Mater Dei | — | Mater Dei | 20:16.00 | 7 |
| 8 | Sophia PopovPlace 8 · Collinsville | — | Collinsville | 20:20.00 | 8 |
| 9 | Ariel IsaakPlace 9 · Mater Dei | — | Mater Dei | 20:23.00 | 9 |
| 10 | Kari WiegmannPlace 10 · Mater Dei | — | Mater Dei | 20:36.00 | 10 |
| 11 | Abby BakerPlace 11 · Alton | — | Alton | 20:39.00 | 11 |
| 12 | Allison BainPlace 12 · Parkway Central | — | Parkway Central | 20:42.00 | 12 |
| 13 | Kathleen WendellPlace 13 · Jersey | — | Jersey | 20:59.00 | 13 |
| 14 | Cecilia TarlasPlace 14 · Parkway Central | — | Parkway Central | 21:07.00 | 14 |
| 15 | Liz odgePlace 15 · Collinsville | — | Collinsville | 21:15.00 | 15 |
| 16 | Emily LeonPlace 16 · Granite City | — | Granite City | 21:34.00 | 16 |
| 17 | Khad Brown-HaywoodPlace 17 · Centralia | — | Centralia | 21:37.00 | 17 |
| 18 | Madelyn MayPlace 18 · Centralia | — | Centralia | 22:01.00 | 18 |
| 19 | Taylore BurlisPlace 19 · Parkway Central | — | Parkway Central | 22:02.00 | 19 |
| 20 | Maggie McCarthyPlace 20 · Collinsville | — | Collinsville | 22:03.00 | 20 |
| 22 | Abby IngenriethPlace 22 · Centralia | — | Centralia | 22:25.00 | 22 |
| 23 | Terri WendlePlace 23 · Jersey | — | Jersey | 22:28.00 | 23 |
| 24 | Clare GreathousePlace 24 · Parkway Central | — | Parkway Central | 22:32.00 | 24 |
| 25 | Taylor MeyerPlace 25 · Collinsville | — | Collinsville | 22:40.00 | 25 |
| 26 | Ellen NikonowiczPlace 26 · Granite City | — | Granite City | 22:41.00 | 26 |
| 27 | Meghan VoumardPlace 27 · Alton | — | Alton | 22:42.00 | 27 |
| 28 | Morgan ThromPlace 28 · Collinsville | — | Collinsville | 22:43.00 | 28 |
| 29 | Dakota ZimmermanPlace 29 · Civic Memorial | — | Civic Memorial | 22:54.00 | 29 |
| 30 | Caroline WalthisPlace 30 · Centralia | — | Centralia | 23:10.00 | 30 |
| 31 | Haley BroylesPlace 31 · Granite City | — | Granite City | 23:13.00 | 31 |
| 32 | Connie YoungPlace 32 · Jersey | — | Jersey | 23:25.00 | 32 |
| 33 | Rachael HoehnPlace 33 · Staunton | — | Staunton | 23:33.00 | 33 |
| 34 | Mabry LewisPlace 34 · Granite City | — | Granite City | 23:48.00 | 34 |
| 35 | Amanda CornellPlace 35 · Staunton | — | Staunton | 24:00.00 | 35 |
| 36 | Anna ScogginsPlace 36 · Alton | — | Alton | 24:22.00 | 36 |
| 37 | Mia StefaniPlace 37 · Staunton | — | Staunton | 24:25.00 | 37 |
| 38 | Carissa PointerPlace 38 · Jersey | — | Jersey | 24:55.00 | 38 |
| 39 | Allee NollmanPlace 39 · Centralia | — | Centralia | 24:57.00 | 39 |
| 40 | Meghan BoydPlace 40 · Alton | — | Alton | 25:07.00 | 40 |
| 41 | Lexi MangoffPlace 41 · Granite City | — | Granite City | 25:22.00 | 41 |
| 42 | Michaela HalwachsPlace 42 · Collinsville | — | Collinsville | 25:40.00 | 42 |
| 43 | Katie WeishauptPlace 43 · Jersey | — | Jersey | 25:42.00 | 43 |
| 44 | Magen CochranPlace 44 · Alton | — | Alton | 25:57.00 | 44 |
| 45 | Megkenzie CaterPlace 45 · Civic Memorial | — | Civic Memorial | 26:08.00 | 45 |
| 46 | Sabyl WhitelowPlace 46 · Centralia | — | Centralia | 26:22.00 | 46 |
| 47 | Lindsey WebbPlace 47 · Civic Memorial | — | Civic Memorial | 26:25.00 | 47 |
| 48 | Emma BowlesPlace 48 · Alton | — | Alton | 26:38.00 | 48 |
| 49 | Carly SchroederPlace 49 · Jersey | — | Jersey | 27:01.00 | 49 |
| 50 | Tessa SchraderPlace 50 · Staunton | — | Staunton | 27:15.00 | 50 |
| 51 | Kyrah PernickaPlace 51 · Staunton | — | Staunton | 27:26.00 | 51 |
| 52 | Courtney LeePlace 52 · Marquette Catholic | — | Marquette Catholic | 28:10.00 | — |
| 53 | Mary LehnenPlace 53 · Civic Memorial | — | Civic Memorial | 28:11.00 | 52 |
| 54 | Megan MasseyPlace 54 · Staunton | — | Staunton | 28:34.00 | 53 |
| 55 | Maddy HaslettPlace 55 · Centralia | — | Centralia | 28:57.00 | 54 |
| 56 | Hannah MullPlace 56 · Civic Memorial | — | Civic Memorial | 32:03.00 | 55 |
| 57 | Katie BowenPlace 57 · Staunton | — | Staunton | 32:34.00 | 56 |
| 58 | Mallory McCunePlace 58 · Civic Memorial | — | Civic Memorial | 37:06.00 | 57 |